منابع مشابه
ATM signalling facilitates repair of DNA double strand breaks associated with heterochromatin
ATM-signalling is essential for the repair of a subset of DNA double strand breaks (DSBs); however its precise role in DSB-repair is unclear. Here, we show that no more than ~25% of DSBs require ATM-signalling for repair and this correlates with increased chromatin complexity but not damage complexity. Importantly, we demonstrate that heterochromatic DSBs are generally repaired more slowly than...
متن کاملATM Release at Resected Double-Strand Breaks Provides Heterochromatin Reconstitution to Facilitate Homologous Recombination
Non-homologous end-joining (NHEJ) and homologous recombination (HR) represent the two main pathways for repairing DNA double-strand breaks (DSBs). During the G2 phase of the mammalian cell cycle, both processes can operate and chromatin structure is one important factor which determines DSB repair pathway choice. ATM facilitates the repair of heterochromatic DSBs by phosphorylating and inactiva...
متن کاملATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
Ataxia Telangiectasia Mutated (ATM) signaling is essential for the repair of a subset of DNA double-strand breaks (DSBs); however, its precise role is unclear. Here, we show that < or =25% of DSBs require ATM signaling for repair, and this percentage correlates with increased chromatin but not damage complexity. Importantly, we demonstrate that heterochromatic DSBs are generally repaired more s...
متن کاملRepair of DNA Double-Strand Breaks in Heterochromatin
DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements. DSBs can be in the form of simple or complex breaks, and may be repaired by one of a number of processes, the nature of which depends on the complexity of the break or the position of the break within the chromat...
متن کاملNew Insights into the Regulation of Heterochromatin.
All living organisms are constantly exposed to stresses from internal biological processes and surrounding environments, which induce many adaptive changes in cellular physiology and gene expression programs. Unexpectedly, constitutive heterochromatin, which is generally associated with the stable maintenance of gene silencing, is also dynamically regulated in response to stimuli. In this revie...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2008
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2008.07.004